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Cytotoxic Residue Monitoring

Quadrupole rods of the second analyzer in the flight tube of triple quadrupole mass spectrometerQCNW provide a cytotoxic residue monitoring service to pharmacy aseptic units handling cytotoxic drugs.

Self-contained kits with all materials necessary for sampling surfaces are supplied. 

Bespoke kits are available for the following compounds, or we can create a kit to suit your requirements:

Kit 1

  • Fluorouracil - LOD = 0.6522ng/cm2
  • Cyclophosphamide - LOD = 0.00236ng/cm2
  • Ifosphamide - LOD = 0.0383ng/cm2
  • Etoposide - LOD = 0.0088ng/cm2 (Melphalan)

Kit 2

  • Cytarabine - LOD = 0.0485ng/cm2
  • Dacarbazine - LOD = 0.0471ng/cm2
  • Mitomycin - LOD = 0.0112ng/cm2

Kit 3

  • Methotrexate - LOD = 0.0033ng/cm2
  • Vincristine - LOD = 0.00477ng/cm2
  • Vinblastine - LOD = 0.0144ng/cm2

Kit 4

  • Gemcitibine - LOD = 0.0041ng/cm2
  • Doxorubicin - LOD = 0.0350ng/cm2
  • Epirubicin - LOD = 0.1340ng/cm2

Platins

  • Carboplatin - LOD = 2.7000ng/cm2
  • Oxaliplatin - LOD = 1.000ng/cm2

Samples are then analysed via LC-MS for traces of cytotoxic residues.